Localization of Neurofibroltlin to Keratinocytes and Melanocytes in Developing Rat and Hultlan Skin
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چکیده
Pigmentation defects are common in the inherited disease type 1 neurofibromatosis (NFl), predicting a role for the NFl gene product, neurofibromin, in the skin. We used immunohistochemistry to determine the distribution of neurofibromin in normal developing and adult rat skin, normal neonatal and adult human skin, and skin from patients affected with NFL The distribution of NFl mRNA in the epidermis was also analyzed by in situ hybridization. NI:1 mRNA and neurofibromin are highly enriched in the keratinocytes in the stratum spinosum of the epidermis in the embryonic, but not adult, rat and in both neonatal and adult humans. Immunoelectron microscopic analysis confirmed
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تاریخ انتشار 2010